A recent study reveals how a compound in the popular beverage disrupts the formation of toxic plaques that contribute to the Alzheimer's disease.
Scientists say that the green tea compound EGCG may help to prevent Alzheimer's disease.Some previous studies have linked green tea to a reduced risk of Alzheimer's, but the mechanisms underlying this link have been unclear. But the recent study reveals how a compound in the popular beverage disrupts the formation of toxic plaques that contribute to the disease.
The study team discovered that the green tea polyphenol epigallocatechin gallate (EGCG) stops the formation of beta-amyloid plaques — a hallmark of Alzheimer's disease — by interfering with the function of beta-amyloid oligomers.
The study lead study author Giuseppe Melacini, of the Departments of Chemistry and Chemical Biology at McMaster University in Canada, and colleagues recently reported their findings in the Journal of the American Chemical Society.
The Alzheimer's disease is a progressive neurodegenerative condition characterized by a decline in memory and thinking,as well as behavioral problems.
Now it is estimated that almost 50 million people worldwide are living with the disease. By 2050, this number is expected to rise to 131.5 million.The actual causes of Alzheimer's disease remain unclear, but it is believed that beta-amyloid plays a key role. This "sticky" protein can clump together, forming plaques that disrupt communication between nerve cells.
Therefore,the new study from Melacini and his team sheds light on how EGCG could help to prevent beta-amyloid plaque formation, bringing us closer to much-needed prevention strategies for Alzheimer's disease.
How EGCG stop creating harmful plaques
The research team came to their findings by using nuclear magnetic resonance to get an in-depth look at how EGCG might affect the formation of beta-amyloid plaques.
And the team explains that beta-amyloid monomers — which are tiny binding molecules— form beta-amyloid oligomers. Over time, these oligomers can stick together and form toxic beta-amyloid plaques.
From their analysis, Melacini and colleagues found that EGCG "remodels" beta-amyloid oligomers, which stops them from creating harmful plaques."At the molecular level," explains Melacini, "we believe EGCG coats toxic oligomers and changes their ability to grow and interact with healthy cells."
The new findings not only support previous studies suggesting that EGCG can help to prevent beta-amyloid plaque formation,but they also shed light on the mechanisms underlying this association.
Green tea could be used to prevent Alzheimer's
On the basis of their findings, the team suggests that extracts from green tea could be used in the prevention of Alzheimer's disease.
"We all know that currently there is no cure for Alzheimer's once symptoms emerge,so our best hope is early intervention. That could mean using green tea extracts or their derivatives early on, say 15 to 25 years before any symptom sever set in." Giuseppe Melacini
The team notes, however, that it is difficult to deliver EGCG directly to the brain, so future research will need to focus on finding ways to modify the compound and overcome this problem.
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